The Sankaran Laboratory uses human genetics to study hematopoiesis and how this process goes awry in human disease. We are particularly interested in gaining molecular insights into how hematopoietic stem and progenitor cells are able to effectively produce mature blood cells and how this process is perturbed in disease, how the hemoglobin genes (including fetal hemoglobin) are regulated, how hematopoiesis varies in humans, and why some individuals may be predisposed to acquiring blood disorders. We are also interested in identifying opportunities to use the insights we gain from our studies to develop improved therapies for a variety of blood disorders, including sickle cell disease, thalassemia, Diamond-Blackfan anemia, aplastic anemia, myelodysplastic syndromes, myeloproliferative disorders, leukemia, and polycythemia. We integrate modern human genetic studies with functional studies employing a variety of cutting-edge genomic technologies and more traditional hematopoietic assays.